Most in-demand Biotech, Diagnostics & Digital Health skills today

Since 2022–2023, the UK life sciences sector has faced a notable decline in venture capital and private investment, particularly in early-stage biotech, diagnostics, and digital health startups. This investment slowdown, driven by global market corrections, inflation, and interest rate hikes, has continued into 2025 with these key impacts:

• Biotech funding fell ~30–50% from peak 2021 levels.
• Digital health startups face tougher scrutiny for ROI and real-world clinical impact.
• Diagnostics firms, especially those without reimbursable pathways, struggle to scale.

Impact on Skills & Hiring

• Fewer R&D-only roles: Companies are prioritizing translational and commercially aligned roles.
• Preference for hybrid skills: Data scientists with biology knowledge; lab scientists with Python/R; regulatory scientists with digital experience.
• Consolidation of roles: Candidates are expected to cover broader scopes (e.g. data analysis + experimental design + stakeholder communication).
• Increased contract/freelance work: Especially in bioinformatics, regulatory support, and digital product development.
• More due diligence in hiring: Emphasis on prior productization, regulatory submissions, or commercial experience over pure academic credentials.

There are still a few areas with growth which include:

1. AI-Driven Drug Discovery

• Skills: Machine learning, deep learning, generative models (e.g., for de novo compound design)
• Tools: Python, TensorFlow, PyTorch, AlphaFold, Chemprop
• Why: AI is increasingly used to predict drug-target interactions, optimize lead compounds, and shorten R&D timelines.

2. Multi-Omics Data Integration

• Skills: Combining genomics, proteomics, transcriptomics, metabolomics
• Tools: R/Bioconductor, Seurat, Scanpy, Cytoscape
• Why: Integrated omics enables deeper understanding of disease mechanisms and more precise target identification.

3. RNA-Based Therapeutics Development

• Skills: mRNA/siRNA design, lipid nanoparticle formulation, in vitro transcription
• Applications: mRNA vaccines, gene silencing therapies
• Why: RNA therapeutics are expanding beyond vaccines into cancer, rare diseases, and autoimmune disorders.

4. Targeted Protein Degradation (e.g., PROTACs, molecular glues)

• Skills: Small molecule design for induced degradation, ubiquitin-proteasome pathway knowledge
• Why: These technologies allow for targeting “undruggable” proteins with high specificity.

5. Single-Cell and Spatial Biology

• Skills: Single-cell RNA-seq, spatial transcriptomics, data interpretation
• Platforms: 10x Genomics, NanoString, Visium
• Why: Offers cell-level insights into tissue heterogeneity and drug response, essential for precision medicine.